Job Board

Our research centers on the mechanisms by which disrupted oxygen homeostasis in regulating fetal growth and maternal vascular adaptation to pregnancy. Using the natural laboratory of high altitude, our work takes advantage of naturally occurring variability between human populations in the frequency of hypoxia-associated vascular disorders of pregnancy to study genes and biologic pathways important for the development of preeclampsia and fetal growth restriction, two interrelated pregnancy complications that constitute a major cause of maternal and infant mortality worldwide. Our long-term goal is to identify potential therapeutic targets to improve maternal and infant health outcomes and to design more effective methods to detect individuals at risk for hypoxia-related disease.